Endocrine Abstracts

Epidemiological studies underline that obesity represents a significant risk factor for development of several cancer among them colon cancer. Moreover, multiple recent data indicate that some of adipose tissue-derived hormones may influence the growth of malignant cells. Leptin, the product of the ob gene, is one of them. However, research is still contradictory regarding the role of leptin in colon cancer.The aim of our study was to examine the ...

Introduction: In many tissues angiotensin peptides acts as the auto/paracrine growth factors. Their effects are dependent on activation of various intracellular signaling pathways, including mitogen-activated protein kinases (MAPK).Angiotensin II (ang II) is the best known angiotensin peptide. The ang II derivatives, angiotensin III (ang III) and angiotensin IV (ang IV) posses biological activity as well. Both ang II and ang IV are known to promote the p...

Introduction: Adrenocortical carcinoma (ACC) is characterized by the high malignancy of the lesion, poor prognosis and high mortality rate. The surgical treatment and available chemotherapy have generally low efficacy so the search for new therapeutic options is still necessary. Some research indicated that thiazolidinediones (TZDs)–synthetic ligands of peroxisome proliferator-activated receptor γ (PPARγ) have oncostatic action on neoplasm, including endocrine t...

Introduction: The peroxisome proliferator-activated receptors gamma (PPARγ) are nuclear receptors which are detected in normal and pathological tissues. Our earlier study showed the overexpression of PPARγ in human adrenal tumors and pituitary adenomas in comparison to normal glands. The in vitro experiments indicated that ligands of PPARγ inhibit growth of many tumors including pituitary adenomas, thyroid cancers and adrenal carcinomas. However, the data...